Blake Biondi’s power-play goal got the Irish within 5-3, but Connor Kurth’s empty-net goal with 1:35 remaining sealed the victory.
Biondi, who transferred to Notre Dame from Minnesota Duluth, added an assist for the Irish.
After Saturday’s series finale in South Bend, the Gophers, who have had just one home game since Nov. 3, will play their next three series — Alaska, Michigan and Michigan State — at home.